REGIONAL CEREBRAL PROTEIN-SYNTHESIS AFTER TRANSIENT ISCHEMIA IN THE RAT - EFFECT OF THE AMPA ANTAGONIST NBQX

被引：17

作者：

FRANK, L ^{[1
]}

BRUHN, T ^{[1
]}

DIEMER, NH ^{[1
]}

机构：

[1] UNIV COPENHAGEN,INST NEUROPATHOL,CEREBRAL ISCHEMIA RES GRP,11 FREDERIK VS VEJ,DK-2100 COPENHAGEN,DENMARK

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 01期

关键词：

ISCHEMIA; RAT; NBQX; NEUROPROTECTION; PROTEIN SYNTHESIS; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(92)90693-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Normothermic rats with 12 min. complete cerebral ischemia were treated with the AMPA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxalinedione (NBQX) [10], which prevents CA1 pyramidal neuron loss. Twenty hours after ischemia, cerebral protein synthesis rate (CPSR) was measured autoradiographically using [S-35]methionine. Ischemia caused a 38% decrease of CPSR in CA1, and postischemic treatment with NBQX caused a 66% decrease in this region. Also treatment with NBQX alone resulted in a decrease (22% in CA1) of the CPSR. Since some evidence exists that the neuroprotective effect of NBQX is related to blockade of the fast AMPA-mediated transmission, the further decrease of the postischemic CPSR in CA1 could be a mere side effect.

引用

页码：108 / 112

页数：5

共 26 条

[1] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].