CLONING OF A NOVEL PUTATIVE G-PROTEIN-COUPLED RECEPTOR (NLR) WHICH IS EXPRESSED IN NEURONAL AND LYMPHATIC TISSUE

被引:16
作者
KOUBA, M
VANETTI, M
WANG, XM
SCHAFER, M
HOLLT, V
机构
[1] UNIV MUNICH,INST PHYSIOL,DEPT PHYSIOL,PETTENKOFERSTR 12,W-8000 MUNICH 2,GERMANY
[2] UNIV MAINZ,DEPT ANAT,W-6500 MAINZ,GERMANY
关键词
G-PROTEIN-COUPLED RECEPTOR; NLR; NG108-15; CELL; POLYMERASE CHAIN REACTION; BLR1; BURKITTS LYMPHOMA; INTERLEUKIN-8;
D O I
10.1016/0014-5793(93)80102-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel G-protein-coupled receptor was isolated from mouse and rat neuronal and lymphatic tissues. The amino acid sequence of the rat receptor (rNLR) shows an overall homology of 80% to a recently cloned receptor from Burkitt's lymphoma cells (BLR1) which is exclusively expressed in lymphatic tissues [(1992) Eur. J. Immunol. 22, 2795]. Much less homology between rNLR and BLR1 was observed at the N-terminus (about 40%), whereas rNLR and the mouse homologue mNLR show 92% amino acid identity. Northern blot analysis of NLR revealed a predominant 5.5 kb mRNA species in various brain regions and neuronal cell lines, whereas in the spleen a 3 kb transcript is predominant. This distribution suggests a role of NLR in the nervous and immune systems.
引用
收藏
页码:173 / 178
页数:6
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