EFFECTS OF TORBAFYLLINE ON MUSCLE ATROPHY - PREVENTION AND RECOVERY

被引：10

作者：

ABOUDRAR, S

DESPLANCHES, D

GRABERVONBERGEN, F

FAVIER, R

OKYAYUZBAKLOUTI, I

HOPPELER, H

机构：

[1] FAC MED LYON, PHYSIOL LAB, CNRS, URA 1341, F-69373 LYON 8, FRANCE

[2] UNIV BERN, DEPT ANAT, CH-3000 BERN, SWITZERLAND

[3] HOECHST WERK ALBERT, DEPT PHARMACOL, WIESBADEN, GERMANY

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1992年 / 70卷 / 06期

关键词：

XANTHINE; RAT MUSCLE CONTRACTION; HISTOCYTOCHEMISTRY; MITOCHONDRIA; CAPILLARIES;

D O I：

10.1139/y92-109

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of torbafylline on the prevention of and the recovery from 5 weeks of hindlimb suspension induced atrophy were analyzed in rat soleus and extensor digitorum longus muscles. Muscle alterations were investigated by determining a suite of electrophysiological, histochemical, and muscle ultrastructural characteristics. Administration of torbafylline during the suspension period was ineffective in preventing any of the observed muscle atrophic changes. Application of torbafylline during the recovery period resulted in a faster recovery of some soleus muscle structural and functional properties. Mitochondrial volume densities and capillary to fiber ratios returned towards baseline values earlier in the recovery process with torbafylline. Furthermore, the drug significantly improved soleus muscle fatigue resistance 4 weeks after cessation of hindlimb suspension.

引用

页码：814 / 820

页数：7

共 27 条

[1] EFFECTS OF CHRONIC TORBAFYLLINE TREATMENT ON ENERGY-METABOLISM OF ISCHEMIC SKELETAL-MUSCLE [J].