GROWTH-HORMONE RESPONSE TO GROWTH HORMONE-RELEASING HORMONE IN EARLY ABSTINENT ALCOHOLIC PATIENTS

被引：7

作者：

DEMARINIS, L ^{[1
]}

MANCINI, A ^{[1
]}

FIUMARA, C ^{[1
]}

CONTE, G ^{[1
]}

IACONA, T ^{[1
]}

IANIRI, L ^{[1
]}

ZEPPETELLI, E ^{[1
]}

GOBBI, G ^{[1
]}

TEMPESTA, E ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE, SCH MED, DEPT PSYCHIAT, I-00168 ROME, ITALY

来源：

PSYCHONEUROENDOCRINOLOGY | 1993年 / 18卷 / 07期

关键词：

D O I：

10.1016/0306-4530(93)90041-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The alpha-2-adrenoceptor agonist clonidine is able to stimulate GHRH secretion directly or via beta-endorphin and, therefore, induces a GH release in normal subjects. This effect has been shown to be blunted in alcoholism during early abstinence, due to central alterations of adrenergic mechanisms. To evaluate pituitary responsiveness to direct stimulation with GHRH, we have studied the GH and PRL response to GHRH in 10 alcoholics during early abstinence. Our data indicate that the pituitary response to GHRH is intact in abstinent alcoholics, except in obese patients, who displayed a blunted GH response. GHRH did not increase PRL. The dissociation between clonidine and GHRH in GH stimulation could reveal a different neuroendocrine mechanism, in comparison with other psychiatric disorders (anorexia nervosa), in which such a dissociation is accompanied by a PRL response to GHRH.

引用

页码：475 / 483

页数：9

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