CELLULOSE-ACETATE BUTYRATE AND POLYCAPROLACTONE FOR KETOPROFEN SPRAY-DRIED MICROSPHERE PREPARATION

被引：37

作者：

GIUNCHEDI, P ^{[1
]}

CONTI, B ^{[1
]}

MAGGI, L ^{[1
]}

CONTE, U ^{[1
]}

机构：

[1] UNIV PAVIA,DEPT PHARMACEUT CHEM,VIALE TARAMELLI 12,I-27100 PAVIA,ITALY

来源：

JOURNAL OF MICROENCAPSULATION | 1994年 / 11卷 / 04期

关键词：

D O I：

10.3109/02652049409034256

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Ketoprofen-loaded microspheres made with a polymeric blend were prepared by a spray-drying technique. Organic solutions of two polymers, cellulose acetate butyrate (CAB) and poly(epsilon-caprolactone) (PCL), in different weight ratios, and of ketoprofen (Ket) were prepared and sprayed, in different experimental conditions, achieving drug-loaded microspheres. The obtained spray-dried microspheres were characterized in terms of yield of production, shape, size, surface properties and drug content, and their in vitro drug release behaviours were determined at different pH values.

引用

页码：381 / 393

页数：13

共 18 条

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