AMIDINIUM CATION AS A MIMIC OF ALLYLIC CARBOCATION - SYNTHESIS AND SQUALENE SYNTHETASE INHIBITORY ACTIVITY OF AN AMIDINIUM ANALOG OF A CARBOCATION INTERMEDIATE

被引:32
作者
PRASHAD, M
机构
[1] Sandoz Research Institute, East Hanover, New Jersey 07936
关键词
D O I
10.1021/jm00057a013
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:631 / 632
页数:2
相关论文
共 11 条
[1]   SYNTHESIS OF AMMONIUM ANALOGS OF CARBOCATIONIC INTERMEDIATES IN THE CONVERSION OF PRESQUALENE DIPHOSPHATE TO SQUALENE [J].
CAPSON, TL ;
THOMPSON, MD ;
DIXIT, VM ;
GAUGHAN, RG ;
POULTER, CD .
JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (25) :5903-5908
[2]  
COPPOLA G, IN PRESS SYNTH COMMU
[3]  
HAFELINGER G, 1975, CHEM AMIDINES IMIDAT, pCH1
[4]   NUCLEOPHILIC REACTIVITY OF ZINC AND COPPER CARBENOIDS .2. [J].
KNOCHEL, P ;
CHOU, TS ;
CHEN, HG ;
YEH, MCP ;
ROZEMA, MJ .
JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (22) :5202-5204
[5]   ALPHA-AMINO CARBANIONS VIA FORMAMIDINES .8. ALKYLATION OF PYRROLIDINES, PIPERIDINES, AND RELATED HETEROCYCLES [J].
MEYERS, AI ;
EDWARDS, PD ;
RIEKER, WF ;
BAILEY, TR .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (11) :3270-3276
[6]   SQUALENE SYNTHETASE INHIBITORS - SYNTHESIS OF SULFONIUM ION MIMICS OF THE CARBOCATIONIC INTERMEDIATES [J].
OEHLSCHLAGER, AC ;
SINGH, SM ;
SHARMA, S .
JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (12) :3856-3861
[7]   SQUALENE SYNTHETASE - INHIBITION BY AMMONIUM ANALOGS OF CARBOCATIONIC INTERMEDIATES IN THE CONVERSION OF PRESQUALENE DIPHOSPHATE TO SQUALENE [J].
POULTER, CD ;
CAPSON, TL ;
THOMPSON, MD ;
BARD, RS .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (10) :3734-3739
[8]  
POULTER CD, 1981, BIOSYNTHESIS ISOPREN, V1, pCH8
[9]   SQUALENE SYNTHETASE - INHIBITION BY AN AMMONIUM ANALOG OF A CARBOCATIONIC INTERMEDIATE IN THE CONVERSION OF PRESQUALENE PYROPHOSPHATE TO SQUALENE [J].
SANDIFER, RM ;
THOMPSON, MD ;
GAUGHAN, RG ;
POULTER, CD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (25) :7376-7378
[10]   SYNTHESIS AND CHARACTERIZATION OF AZA ANALOG INHIBITORS OF SQUALENE AND GERANYLGERANYL DIPHOSPHATE SYNTHASES [J].
STEIGER, A ;
PYUN, HJ ;
COATES, RM .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (12) :3444-3449