ADSORPTION LIQUID-CHROMATOGRAPHY ON COLUMNS - RATIONAL METHOD OF MOBILE PHASE OPTIMIZATION BASED ON THE USE OF ISOHYDRIC SOLVENTS

被引：27

作者：

THOMAS, JP

BRUN, A

BOUNINE, JP

机构：

[1] Rhöne-Poulenc, Direction des Recherches et du Développement, Centre de Recherches Nicolas Grillet, 94400 Vitry-sur-Seine

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 172卷 / APR期

关键词：

D O I：

10.1016/S0021-9673(00)90950-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In order to facilitate the use and automation of liquid column chromatography in control laboratories, we have made a classification and a rational combination of solvents. By using an experimental determination of polarity, based on the water content of previously defined isohydric solvents, we have elaborated a method for the optimization of separations that considerably reduces the operating time, gives a more accurate description of processes and greatly limits the number of systems able to solve most of the problems. Practical separations of drug formulations, barbiturates, aromatic bases and phenothiazines are considered. © 1979.

引用

页码：107 / 130

页数：24

共 39 条

[1] [Anonymous], 2021, AACR ANN M APR MAY
[2] GRADIENT OPTIMIZATION IN ELUTION LIQUID-CHROMATOGRAPHY .1. THEORETICAL CONSIDERATIONS CONNECTED WITH EVALUATION OF CONCENTRATION-TIME FUNCTION FOR STEPWISE ELUTION
BOROWKO, M
JARONIEC, M
NARKIEWICZ, J
PATRYKIEJEW, A
RUDZINSKI, W
[J]. JOURNAL OF CHROMATOGRAPHY, 1978, 153 (02): : 309 - 319
[3] HIGH-SPEED LIQUID-SOLID CHROMATOGRAPHY OF PHENOTHIAZINES USING COLUMNS PACKED WITH SPHEROSIL POROUS SILICA BEADS
CAUDE, M
LEXUANPHAN
TERLAIN, B
THOMAS, JP
[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1975, 13 (08) : 390 - 396
[4] INVESTIGATIONS OF RELATIONSHIP BETWEEN MOLECULAR-STRUCTURE AND CHROMATOGRAPHIC PARAMETERS .9. EXTRACTION OF PHENOLIC 2-BENZOYLBENZOIC ACIDS WITH CYCLOHEXANE SOLUTIONS OF NORMAL HEXANOL AND OLEIC ACID
CISZEWSKA, M
SOCZEWINSKI, E
[J]. JOURNAL OF CHROMATOGRAPHY, 1975, 111 (01): : 21 - 27
[5] TRANSPOSITION TO COLUMNS OF DATA OBTAINED IN LIQUID-SOLID THIN-LAYER CHROMATOGRAPHY
COQ, B
NICOLAS, JP
LAMOTTE, A
PORTHAUL.M
[J]. JOURNAL OF CHROMATOGRAPHY, 1974, 97 (02): : 137 - 150
[6] OPTIMIZATION OF REVERSE-PHASE LIQUID-CHROMATOGRAPHIC SEPARATION OF WEAK ORGANIC-ACIDS
DEMING, SN
TUROFF, MLH
[J]. ANALYTICAL CHEMISTRY, 1978, 50 (04) : 546 - 548
[7] INFLUENCE OF ALKALINITY IN THIN-LAYER CHROMATOGRAPHY SYSTEMS FOR SEPARATION OF IMPURITIES IN CHLORPROMAZINE, PROMAZINE AND PROMETHAZINE
FRENCH, WN
MATSUI, FF
ROBERTSON, DL
SMITH, SJ
[J]. JOURNAL OF CHROMATOGRAPHY, 1974, 97 (02): : 223 - 231
[8] SEPARATION OF HERBICIDES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - INFLUENCE OF WATER
GONNET, C
ROCCA, JL
[J]. JOURNAL OF CHROMATOGRAPHY, 1975, 109 (02): : 297 - 303
[9] SPHEROSIL FOR HIGH-PERFORMANCE, MODERATE-PRESSURE LIQUID-CHROMATOGRAPHY
GUILLEMIN, CL
THOMAS, JP
THIAULT, S
BOUNINE, JP
[J]. JOURNAL OF CHROMATOGRAPHY, 1977, 142 (NOV): : 321 - 337
[10] SYSTEMATIC DESIGN OF BINARY SOLVENT SYSTEMS FOR LIQUID-SOLID CHROMATOGRAPHY VIA RETENTION BEHAVIOR OF MONO-FUNCTIONAL AND DI-FUNCTIONAL STEROIDS ON SILICA-GEL COLUMNS
HARA, S
FUJII, Y
HIRASAWA, M
MIYAMOTO, S
[J]. JOURNAL OF CHROMATOGRAPHY, 1978, 149 (FEB): : 143 - 159

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