IRREVERSIBLE ENZYME INHIBITORS .166. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)PYRIMIDINE WITH 6 SUBSTITUENTS AND SOME FACTORS IN THEIR CELL WALL TRANSPORT

被引：10

作者：

BAKER, BR

VERMEULE.NM

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1970年 / 13卷 / 01期

关键词：

D O I：

10.1021/jm00295a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

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页码：82 / &

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[1] IRREVERSIBLE ENZYME INHIBITORS .160. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-L-(PHENYLALKYLPHENYL)-S-TRIAZINES
BAKER, BR
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VERMEULEN, NM
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[2] IRREVERSIBLE ENZYME INHIBITORS .165. PROTEOLYTIC ENZYMES .15. INHIBITION OF GUINEA PIG COMPLEMENT BY DERIVATIVES OF M-PHENOXYPROPOXYBENZAMIDINE
BAKER, BR
CORY, M
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (06) : 1053 - &
[3] IRREVERSIBLE ENZYME INHIBITORS .158. EFFECT OF BRIDGE MODIFICATION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-[P-(M-FLUOROSULFONYLBENZAMIDOMETHYL)PHENOXYMETHYL]PYRIMIDINE .2.
BAKER, BR
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (04) : 684 - +
[4] BAKER BR, 1969, J MED CHEM, V12, P680, DOI 10.1021/jm00304a027
[5] BAKER BR, 1969, J MED CHEM, V12, P89, DOI 10.1021/jm00301a023
[6] IRREVERSIBLE ENZYME INHIBITORS . 136 . 2,4- DIAMINO-5-(3,4-DICHLOROPHENYL)-6-(P-(M-FLUOROSULFONYLBENZAMIDO)PHENOXYMETHYL)PYRIMIDINE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE . EFFECT OF STRUCTURE ON ISOZYME SPECIFICITY
BAKER, BR
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) : 82 - +
[7] BAKER BR, 1969, J MED CHEM, V12, P74, DOI 10.1021/jm00301a019
[8] IRREVERSIBLE ENZYME INHIBITORS . 133 . STUDIES ON DIFFERENTIAL IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM 3 STRAINS OF L1210 LEUKEMIA LIVER SPLEEN AND INTESTINE OF MOUSE
BAKER, BR
LOURENS, GJ
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[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) : 67 - +
[9] BAKER BR, 1968, J MED CHEM, V11, P475, DOI 10.1021/jm00309a015
[10] IRREVERSIBLE ENZYME INHIBITORS . 135 . EFFECT OF RING SUBSTITUTION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-(P-(P-FLUOROSULFONYLPHENYLUREIDO)PHENOXYMETHYL)PYRIMIDINE
BAKER, BR
VERMEULEN, NM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) : 79 - +