TANDEM MICHAEL REACTIONS FOR THE CONSTRUCTION OF PYRROLIDINE AND PIPERIDINE RING-SYSTEMS

被引:26
作者
BARCO, A [1 ]
BENETTI, S [1 ]
CASOLARI, A [1 ]
POLLINI, GP [1 ]
SPALLUTO, G [1 ]
机构
[1] DIPARTIMENTO SCI FARMACEUT,I-44100 FERRARA,ITALY
关键词
D O I
10.1016/S0040-4039(00)89020-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A convergent one-pot construction of disubstituted pyrrolidine and piperidine frameworks has been accomplished through a simple protocol involving intermolecular conjugate addition of a nitrogen nucleophile to an electrophilic olefin followed by intramolecular trapping of the generated enolate by a built-in α,β,-unsaturated acceptor. © 1990.
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页码:3039 / 3042
页数:4
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