CERULOPLASMIN ELEVATION AND SYNTHESIS IN RATS WITH TRANSPLANTABLE TUMORS

被引：25

作者：

LINDER, MC ^{[1
]}

BRYANT, RR ^{[1
]}

LIM, S ^{[1
]}

SCOTT, LE ^{[1
]}

MOOR, JE ^{[1
]}

机构：

[1] MIT,DEPT NUTR & FOOD SCI,PHYSIOL CHEM LAB,CAMBRIDGE,MA 02139

来源：

ENZYME | 1979年 / 24卷 / 02期

关键词：

D O I：

10.1159/000458636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In rats with transplantable mammary or hepatic tumors, plasma ceruloplasmin oxidase activity was increased 50-200%. This occurred progressively with tumors weighing 0.3% of body weight or more, and did not occur upon sham operation or implantation of normal tissue. Incorporation of (3H)-leucine indicated a specific enhancement of ceruloplasmin synthesis in the tumor-bearing rats, and a greater state of activation of the enzyme was also observed. The mechanism of the increase in ceruloplasmin levels in rats and humans with cancer thus appears to involve increased synthesis and activation of the enzyme.

引用

页码：85 / 95

页数：11

共 21 条

[1] IMPROVED SCINTILLATION COCKTAIL OF HIGH-SOLUBILIZING POWER [J].

ANDERSON, LE ;

MCCLURE, WO .

ANALYTICAL BIOCHEMISTRY, 1973, 51 (01) :173-179

[2] A SOLUBILIZABLE ACRYLAMIDE GEL FOR ELECTROPHORESIS [J].

ANKER, HS .

FEBS LETTERS, 1970, 7 (03) :293-&

[3] SERUM COPPER AND CERULOPLASMIN IN PREGNANCY [J].

BURROWS, S ;

PEKALA, B .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1971, 109 (06) :907-&

[4] DISC ELECTROPHORESIS .2. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS [J].

DAVIS, BJ .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1964, 121 (A2) :404-&

[5]

HRGOVCIC M, 1973, CANCER-AM CANCER SOC, V31, P1337, DOI 10.1002/1097-0142(197306)31:6<1337::AID-CNCR2820310606>3.0.CO

[6]

2-W

[7]

HSIEH HS, 1975, BIOCHEM BIOPH RES CO, V67, P1326

[8]

KNOX WE, 1969, CANCER RES, V29, P669

[9]

LINDER MC, ENZYME

[10]

LINDER MC, 3RD P INT C DET PREV

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