I-125-INSULIN IS PREFERENTIALLY INTERNALIZED IN REGIONS OF THE HEPATOCYTES RICH IN LYSOSOMAL AND GOLGI STRUCTURES

被引：12

作者：

CARPENTIER, JL

GORDEN, P

FREYCHET, P

LECAM, A

ORCI, L

机构：

[1] Institute of Histology and Embryology, Geneva University School of Medicine, Geneva 4

来源：

EXPERIENTIA | 1979年 / 35卷 / 07期

关键词：

D O I：

10.1007/BF01955140

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

125I-Insulin initially localizes to the plasma membrane of isolated rat hepatocytes but is subsequently internalized and preferentially associates with lysosomal structures. In the present study, we show that this preferential association to lysosomes occurs in regions of the cell rich in lysosomal and Golgi structures. © 1979 Birkhäuser Verlag.

引用

页码：904 / 906

页数：3

共 10 条

[1] I-125 INSULIN BINDING TO CULTURED HUMAN LYMPHOCYTES - INITIAL LOCALIZATION AND FATE OF HORMONE DETERMINED BY QUANTITATIVE ELECTRON-MICROSCOPIC AUTORADIOGRAPHY
CARPENTIER, JL
GORDEN, P
AMHERDT, M
VANOBBERGHEN, E
KAHN, CR
ORCI, L
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (04) : 1057 - 1070
[2] CARPENTIER JL, 1977, DIABETOLOGIA, V13, P386
[3] CARPENTIER JL, J CLIN INVEST
[4] CARPENTIER JL, UNPUBLISHED
[5] CARPENTIER JL, 1978, DIABETOLOGIA, V14, P224
[6] FREYCHET P, 1976, METHODS RECEPTOR R 2, P385
[7] INTRACELLULAR TRANSLOCATION OF IODINE-125-LABELED INSULIN - DIRECT DEMONSTRATION IN ISOLATED HEPATOCYTES
GORDEN, P
CARPENTIER, JL
FREYCHET, P
LECAM, A
ORCI, L
[J]. SCIENCE, 1978, 200 (4343) : 782 - 785
[8] ROUILLER C, 1963, LIVER, V1, P195
[9] Seglen P O, 1976, Methods Cell Biol, V13, P29, DOI 10.1016/S0091-679X(08)61797-5
[10] Weibel E R, 1969, Int Rev Cytol, V26, P235, DOI 10.1016/S0074-7696(08)61637-X

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