ANTIBODY IS RESPONSIBLE FOR THE PASSIVE TRANSFER OF IMMUNITY TO MICE FROM RABBITS, RATS OR MICE VACCINATED WITH ATTENUATED SCHISTOSOMA-JAPONICUM CERCARIAE

被引:27
作者
MOLONEY, NA
WEBBE, G
机构
[1] London School of Hygiene and Tropical Medicine, London WC1E 7HT, Keppel Street
基金
英国医学研究理事会;
关键词
D O I
10.1017/S0031182000061230
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Sera from rabbits, rats and mice multiply-vaccinated with attenuated cercariae of Schistosoma japonicum conferred high levels of resistance against challenge to naive recipient mice (up to 97, 64 and 60% respectively). Vaccinated rabbit and rat sera were given before challenge and vaccinated mouse serum 5 days after challenge. To show that the protective factors in these sera were antibodies, vaccinated rabbit and mouse sera were fractionated by protein A-Sepharose and the fractions precipitated by 50% ammonium sulphate. The protein A-Sepharose binding or non-binding fractions in vaccinated rabbit serum transferred approximately equal levels of significant resistance to mice, suggesting that both the IgG and non-IgG components of vaccinated rabbit serum are protective. The major part of the protective activity in vaccinated mouse serum was transferred to recipients by the protein A-Sepharose binding fraction, i.e. the IgG antibodies. Heat inactivation of sera at 56°C for 3 h affected the protective capacity of vaccinated rat sera, but not that of vaccinated rabbit or mouse sera. © 1990, Cambridge University Press. All rights reserved.
引用
收藏
页码:235 / 239
页数:5
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