NASAL ABSORPTION IN RATS .2. EFFECT OF ENHANCERS ON INSULIN ABSORPTION AND NASAL HISTOLOGY

被引：47

作者：

CHANDLER, SG ^{[1
]}

ILLUM, L ^{[1
]}

THOMAS, NW ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,QUEENS MED CTR,DEPT HUMAN MORPHOL,NOTTINGHAM NG7 2RD,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 76卷 / 1-2期

关键词：

INTRANASAL ADMINISTRATION; INSULIN; ABSORPTION ENHANCER; NASAL HISTOLOGY; LAURETH-9; SODIUM TAURODIHYDROFUSIDATE; L-ALPHA-LYSOPHOSPHATIDYLCHOLINE; DEAE-DEXTRAN;

D O I：

10.1016/0378-5173(91)90344-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intranasal formulations have been investigated using a combined absorption and histological model to determine the effects of different absorption enhancers on insulin uptake and nasal epithelium integrity. Based on changes in blood glucose enhancers were ranked according to their insulin absorption promoting effect, while qualitative histological assessment enabled ranking according to the severity of epithelium disruption. Despite a close relationship between the two effects, removal of the epithelial barrier was not considered to be the only mechanism of action for all of the enhancers studied and other factors require further investigation. The model used enables early assessment of compounds from both an enhancing efficiency and toxicological standpoint.

引用

页码：61 / 70

页数：10

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