LONG-TERM EFFECTIVENESS OF LOW-DOSE MITHRAMYCIN FOR PAGETS-DISEASE OF BONE

被引：13

作者：

RUSSELL, AS

CHALMERS, IM

PERCY, JS

LENTLE, BC

机构：

[1] UNIV NATAL, DEPT MED, DURBAN, SOUTH AFRICA

[2] UNIV ALBERTA, DEPT NUCL MED, EDMONTON T6G 2G3, ALBERTA, CANADA

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 03期

关键词：

D O I：

10.1002/art.1780220302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nineteen patients with Paget's disease of bone were studied 7 months to 5 years after therapy with mithramycin in a dose averaging 11.5 μg/kg body weight daily for 10 days. Thirteen patients, including 3 with the longest followup intervals, remained free of pain. Objective measures of disease activity (serum alkaline phosphatase level and 99mtechnetium pyrophosphate bone scan) were less favorable. There was no evidence of long term toxicity. Copyright © 1979 American College of Rheumatology

引用

页码：215 / 218

页数：4

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