2 NOVEL, POTENT AND SELECTIVE HISTAMINE H-3 RECEPTOR AGONISTS

被引：41

作者：

HOWSON, W

PARSONS, ME

RAVAL, P

SWAYNE, GTG

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT LTD,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

[2] PFIZER LTD,SANDWICH C213 9NJ,KENT,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80659-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

S-[2-(4-(5)-imidazoyl)ethyl]isothiourea (1) and 4-(4-(5)-imidazoyl)butyramidine (2) were shown to be potent H-3 agonists on the guinea-pig ileum with very little activity on H-1 and H-2 receptor preparations.

引用

页码：77 / 78

页数：2

共 10 条

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[2] HIGHLY POTENT AND SELECTIVE LIGANDS FOR HISTAMINE RECEPTORS-H-3
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[5] RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE
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[6] DEFINITION AND ANTAGONISM OF HISTAMINE H2-RECEPTORS
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[J]. NATURE, 1972, 236 (5347) : 385 - &
[7] BLACK JW, 1976, Patent No. 3954982
[8] BLACK JW, 1973, Patent No. 3759994
[9] DIMAPRIT - [S-[3-(N,N-DIMETHYLAMINO)PROPYL]ISOTHIOUREA] - HIGHLY SPECIFIC HISTAMINE H2-RECEPTOR AGONIST .1. PHARMACOLOGY
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OWEN, DAA
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DURANT, GJ
[J]. AGENTS AND ACTIONS, 1977, 7 (01): : 31 - 37
[10] TRZECIAKOWSKI JP, 1987, J PHARMACOL EXP THER, V243, P874

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