ACUTE-INFLAMMATION ENHANCES SUBSTANCE P-INDUCED PLASMA-PROTEIN EXTRAVASATION IN THE RAT KNEE-JOINT

被引：30

作者：

SCOTT, DT ^{[1
]}

LAM, FY ^{[1
]}

FERRELL, WR ^{[1
]}

机构：

[1] UNIV GLASGOW, INST PHYSIOL, GLASGOW G12 8QQ, SCOTLAND

来源：

REGULATORY PEPTIDES | 1992年 / 39卷 / 2-3期

关键词：

SUBSTANCE-P; JOINT INFLAMMATION; CARRAGEENAN; PROTEIN EXTRAVASATION;

D O I：

10.1016/0167-0115(92)90543-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute inflammation of the rat knee joint was induced by intra-articular injection of 2% carrageenan. Intra-articular perfusion of the inflamed joint with substance P (SP) exacerbated the inflammatory condition as assessed by the degree of plasma protein extravasation into the synovial cavity. Protein extravasation induced by SP was enhanced and more persistent in the inflamed rat knee compared to normal animals. The time course of the response in the inflamed rat knee was related to SP concentration whilst the persistency of the response was positively correlated with the initial level of joint inflammation.

引用

页码：227 / 235

页数：9

共 15 条

[1]

DIROSA M, 1972, J PHARM PHARMACOL, V24, P89, DOI 10.1111/j.2042-7158.1972.tb08940.x

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