HOW TO ESTIMATE THE TOTAL RECEPTOR CONCENTRATION WHEN THE SPECIFIC RADIOACTIVITY OF THE LIGAND IS UNKNOWN

被引：48

作者：

SWILLENS, S

机构：

[1] S. Swillens is Chargé de Cours, the Institut de Recherche Interdisciplinaire, Université Libre de Bruxelles, B 1070 Brussels, Campus Erasme, bat. C

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 12期

关键词：

D O I：

10.1016/0165-6147(92)90139-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A computation method is presented allowing a direct determination of the total receptor concentration from a competitive displacement curve. Compared to the classical method based on the numerical processing of binding data, the proposed method has the advantage of being more accurate and of not requiring knowledge of the specific radioactivity of the ligand.

引用

页码：430 / 434

页数：5

共 5 条

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[3]

JOHNSON ML, 1985, METHOD ENZYMOL, V117, P301

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