PHARMACOKINETICS OF THE GARLIC COMPOUND S-ALLYLCYSTEINE

被引：127

作者：

NAGAE, S

USHIJIMA, M

HATONO, S

IMAI, J

KASUGA, S

MATSUURA, H

ITAKURA, Y

HIGASHI, Y

机构：

[1] WAKUNAGA PHARMACEUT CO LTD,KODA,HIROSHIMA 72964,JAPAN

[2] HIROSHIMA UNIV,SCH MED,INST PHARMACEUT SCI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

PLANTA MEDICA | 1994年 / 60卷 / 03期

关键词：

ALLIUM SATIVUM; ALLIACEAE; S-ALLYLCYSTEINE; PHARMACOKINETICS; N-ACETYL-S-ALLYLCYSTEINE; GARLIC;

D O I：

10.1055/s-2006-959461

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The pharmacokinetic behavior of S-allylcysteine (SAC), one of the biologically active transformation products from garlic, was investigated after oral administration to rats, mice, and dogs. SAC was rapidly and easily absorbed in the gastrointestinal tract and distributed mainly in plasma, Liver, and kidney. The bioavailability was 98.2, 103.0, and 87.2 % in rats, mice, and dogs, respectively. SAC was mainly excreted into urine in the N-acetyl form in rats; however, mice excreted both SAC and the N-acetyl form. The half-life of SAC was longer in dogs than in rats and mice.

引用

页码：214 / 217

页数：4

共 13 条

[1] THE ORGANOSULFUR CHEMISTRY OF THE GENUS ALLIUM - IMPLICATIONS FOR THE ORGANIC-CHEMISTRY OF SULFUR [J].