ACUTE URIC-ACID NEPHROPATHY

被引：50

作者：

CONGER, JD ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DENVER,CO 80262

来源：

MEDICAL CLINICS OF NORTH AMERICA | 1990年 / 74卷 / 04期

关键词：

D O I：

10.1016/S0025-7125(16)30522-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Uric acid, the end product of purine metabolism in humans, is relatively insoluble at high concentrations in the acid environment of the distal nephrons of the kidney. In states of rapid cellular turnover or lysis, such as neoplastic disorders before or during treatment, large amounts of urate are formed. Urate and uric acid precipitate within the kidney, causing acute intrarenal obstruction and renal failure. Critical to the diagnosis is oliguria and marked hyperuricemia in a setting of accelerated cellular breakdown. Therapy consists of prophylactic use of xanthine oxidase inhibitors and alkaline diuresis. Dialysis occasionally is required when renal dysfunction is severe.

引用

页码：859 / 871

页数：13

共 28 条

[1] PURINE EXCRETION DURING TUMOR LYSIS IN CHILDREN WITH ACUTE LYMPHOCYTIC-LEUKEMIA RECEIVING ALLOPURINOL - RELATIONSHIP TO ACUTE-RENAL-FAILURE [J].