ANTIBODIES TO BORDETELLA-PERTUSSIS ADENYLATE-CYCLASE ARE PRODUCED IN MAN DURING PERTUSSIS INFECTION AND AFTER VACCINATION

被引：30

作者：

FARFEL, Z

KONEN, S

WIERTZ, E

KLAPMUTS, R

ADDY, PAK

HANSKI, E

机构：

[1] WEIZMANN INST SCI, DEPT HORMONE RES, IL-76100 REHOVOT, ISRAEL

[2] SHEBA MED CTR, DEPT MED E, IL-51621 TEL HASHOMER, ISRAEL

[3] TEL AVIV UNIV, SACKLER SCH MED, TEL AVIV, ISRAEL

[4] NATL INST PUBL HLTH & ENVIRONM PROTECT, 3720 BA BILTHOVEN, NETHERLANDS

[5] UNIV SCI & TECHNOL, SCH MED SCI, DEPT CLIN MICROBIOL, KUMASI, GHANA

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1990年 / 32卷 / 03期

关键词：

D O I：

10.1099/00222615-32-3-173

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bordetella pertussis produces several potential virulence factors. One of these is an adenylate cyclase which penetrates eukaryotic cells, is activated by calmodulin and generates high levels of intracellular cAMP. We have found that pertussis infection in man leads to production of high titres (2000-8000) of anti-B. pertussis adenylate cyclase antibodies. Such antibodies also are produced after pertussis vaccination. They persist into adulthood, cross the placenta and disappear a few months after birth. The anti-adenylate cyclase antibodies found in human serum during pertussis infection do not neutralise the catalytic and penetrative activities of the enzyme.

引用

页码：173 / 177

页数：5

共 29 条

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