STUDY OF ALPHA-THALASSEMIA IN NORTHEASTERN THAILAND AT THE DNA LEVEL

被引：9

作者：

HUNDRIESER, J

LAIG, M

YONGVANIT, P

SRIBOONLUE, P

SANGUANSERMSRI, T

KUHNAU, W

PAPE, M

FLATZ, G

机构：

[1] KHON KAEN UNIV,FAC MED,DEPT BIOCHEM,KHON KAEN,THAILAND

[2] CHIANG MAI UNIV,FAC MED,HUMAN GENET UNIT,CHIANG MAI,THAILAND

来源：

HUMAN HEREDITY | 1990年 / 40卷 / 02期

关键词：

Hemoglobin Constant Spring; Population study; Thailand; α-Thalassemia;

D O I：

10.1159/000153911

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The frequency of α-thalassemias in a general population sample from northeastern Thailand and in an Austroasiatic group with high frequencies of hemoglobin E and β-thalassemia, the So, was estimated using DNA techniques. Among 64 healthy adult subjects from the Khonkaen and Ubol areas, the following haplotype frequencies were determined: αα, 0.742; -α3.7 (subtype I), 0.148; -α4.2, 0.016; -α(del), 0.008; α(Constant Spring)α, 0.055; --(SEA), 0.023, and ααα (triplicated α-globin gene), 0.008. In the So group, the combined frequency of α-thalassemia chromosomes was 0.525.

引用

页码：85 / 88

页数：4

共 11 条

[1] CHARACTERIZATION OF 2 DELETIONS THAT REMOVE THE ENTIRE HUMAN ZETA-ALPHA-GLOBIN GENE-COMPLEX (--THAI AND --FIL) [J].