IMMUNOTHERAPY OF AN ASCITIC RAT HEPATOMA WITH CORD FACTOR (TREHALOSE-6, 6'-DIMYCOLATE) AND SYNTHETIC ANALOGS

被引：43

作者：

PIMM, MV ^{[1
]}

BALDWIN, RW ^{[1
]}

POLONSKY, J ^{[1
]}

LEDERER, E ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91190 GIF SUR YVETTE,FRANCE

来源：

INTERNATIONAL JOURNAL OF CANCER | 1979年 / 24卷 / 06期

关键词：

D O I：

10.1002/ijc.2910240614

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ability of cord factor (trehalose‐6, 6′‐dimycolate) and a range of shorter carbon chain fatty acid trehalose diesters to suppress growth of an ascitic rat hepatoma has been examined and compared with that of whole, living BCG organisms. Aqueous suspensions of BCG, and cord factor in 0.4% arachis oil:Triton emulsion, injected intra‐peritoneally, retarded growth of up to 105 ascites tumour cells. Trehalose‐6, 6′‐dibehenate was also tumour‐suppressive, but only against lower challenge inocula (104 cells). Trehalose‐6, 6′‐dipalmitate and 6,6′‐di‐0–2‐tetradecyl ‐3‐hydroxyoctadecanoyl β,β trehalose (designated C76) were virtually ineffective and 6,6′ ‐di‐0–2‐eicosyl‐3‐hydroxy‐tetracosanoyl β, β trehalose (designated C100) gave small and variable effects only against low challenge inocula. However, improved responses were seen with light mineral oil in place of arachis oil in the emulsions. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：780 / 785

页数：6

共 27 条

[1]

Baldwin R W, 1978, Adv Cancer Res, V28, P91, DOI 10.1016/S0065-230X(08)60647-8

[2]

BALDWIN RW, 1979, SPRINGER SEMIN IMMUN, V2, P79

[3] IMMUNOTHERAPY OF CANCER WITH NONLIVING MYCOBACTERIA AND CORD FACTOR (TREHALOSE-6,6'-DIMYCOLATE) IN AQUEOUS-MEDIUM [J].