IDENTIFICATION AND LOCALIZATION OF WOUND HYALURONIDASE

被引：15

作者：

ALEXANDER, SA ^{[1
]}

DONOFF, RB ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH DENT MED,BOSTON,MA 02114

来源：

JOURNAL OF SURGICAL RESEARCH | 1979年 / 27卷 / 03期

关键词：

D O I：

10.1016/0022-4804(79)90126-4

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A method for tissue localization of hyaluronidase by a substrate film was used to study the time course and location of enzymatic activity in healing open rabbit wounds. Optically clear areas which were devoid of toluidine blue metachromasia indicated degradation of hyaluronate by hyaluronidase. Central granulation tissue exhibited hyaluronidase activity on the seventh postwound day, while whole edge tissue did not show activity until Day 18. The current work also compares the healing wound to other developmental systems in which hyaluronic acid has been implicated in morphogenesis, and where the appearance of hyaluronidase has been correlated to cytodifferentiation. © 1979.

引用

页码：163 / 167

页数：5

共 25 条

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