AUDIOGENIC-SEIZURES INDUCE C-FOS IN A MODEL OF DEVELOPMENTAL EPILEPSY

被引：63

作者：

SNYDERKELLER, AM

PIERSON, MG

机构：

[1] Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany

来源：

NEUROSCIENCE LETTERS | 1992年 / 135卷 / 01期

关键词：

C-FOS; AUDIOGENIC SEIZURE; INFERIOR COLLICULUS; EPILEPSY; MK-801;

D O I：

10.1016/0304-3940(92)90147-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In rats made susceptible to audiogenic seizures by exposing them to an intense noise at a critical time during development, subsequent noise exposure elicited seizures and induced the proto-oncogene c-fos in auditory regions of the brain. Cells showing Fos-like immunoreactivity were especially dense in dorsal and external cortices of the inferior colliculus, and were nearly absent after pretreatment with the N-methyl-D-aspartate (NMDA) antagonist MK-801. Noise exposure alone (i.e. no seizure) produced a localized zone of c-fos induction within the inferior colliculus, but only when presented during the time period when susceptibility to audiogenic seizures can be most effectively induced.

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页码：108 / 112

页数：5

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