A CORRELATION STUDY BETWEEN BLINK REFLEX HABITUATION AND CLINICAL STATE IN PATIENTS WITH PARKINSONS-DISEASE

被引:19
作者
MATSUMOTO, H
NORO, H
KANESHIGE, Y
CHIBA, S
MIYANO, N
MOTOI, Y
YANADA, Y
机构
[1] Department of Rehabilitation and Neurology, Sapporo Medical College, Sapporo
关键词
BLINK REFLEX; BLINK REFLEX HABITUATION; PARKINSONS DISEASE;
D O I
10.1016/0022-510X(92)90283-Q
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The neurologic states and activities of daily life of patients with Parkinson's disease were evaluated using a rating scale with subitems. and subsequently the neurologic disturbance scores and the daily activity impairment scores were obtained. Subjects consisted of 19 normal controls, and 55 ambulatory patients without marked dyskinesia who were on various anti-parkinsonian drugs. Blink reflex was elicited by paired electrical stimulation over the supraorbital nerve. The interval time between the conditioning stimulation and the test stimulation was set at 200 ms, and 5 serial ipsilateral maximal R2 amplitudes on the stimulated side were measured. The mean of the paired maximal R2 amplitude ratio (test/conditioning), expressed as a percentage, was defined as the habituation index. The habituation indices in normal controls and those with Parkinson's disease were 17.1 +/- 7.6 and 51.9 +/- 29.3, respectively (P < 0.01). The degree of akinesia, rigidity, balance/gait and dysarthria was positively correlated with the habituation index (P < 0.01), while tremor was not. On the whole the habituation index was found to have a significantly correlation not only with the neurologic disturbance score but also with the daily activity impairment score (P < 0.01).
引用
收藏
页码:155 / 159
页数:5
相关论文
共 21 条
[1]  
BYNKE O, 1975, ACTA NEUROL SCAN S76, V62, P5
[2]   ELECTROPHYSIOLOGICAL STUDY OF SOME TRIGEMINOFACIAL REFLEXES IN PARKINSONS-DISEASE BEFORE AND AFTER L-DOPAM ADMINISTRATION [J].
CACCIA, MR ;
AVANZINI, G ;
NEGRI, S .
EUROPEAN NEUROLOGY, 1972, 8 (06) :339-351
[3]   HABITUATION OF ORBICULARIS OCULI REFLEX IN DEMENTIA AND DYSKINETIC STATES [J].
FERGUSON, IT ;
LENMAN, JAR ;
JOHNSTON, BB .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1978, 41 (09) :824-828
[4]   NEURAL MECHANISMS OF CORNEAL BLINKING REFLEX IN CATS [J].
HIRAOKA, M ;
SHIMAMURA, M .
BRAIN RESEARCH, 1977, 125 (02) :265-275
[5]   PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].
HOEHN, MM ;
YAHR, MD .
NEUROLOGY, 1967, 17 (05) :427-&
[6]  
Iriarte L M, 1988, Funct Neurol, V3, P147
[7]   BLINK REFLEX IN DYSKINETIC AND NONDYSKINETIC PATIENTS WITH PARKINSONS-DISEASE [J].
IRIARTE, LM ;
CHACON, J ;
MADRAZO, J ;
CHAPARRO, P ;
VADILLO, J .
EUROPEAN NEUROLOGY, 1989, 29 (02) :67-70
[8]  
KARSON CN, 1979, AM J PSYCHIAT, V136, P1057
[9]   ORBICULARIS OCULI REFLEX IN WALLENBERG SYNDROME - ALTERATION OF LATE REFLEX BY LESIONS OF SPINAL TRACT AND NUCLEUS OF TRIGEMINAL NERVE [J].
KIMURA, J ;
LYON, LW .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1972, 35 (02) :228-+
[10]   DISORDER OF INTERNEURONS IN PARKINSONISM - ORBICULARIS OCULI REFLEX TO PAIRED STIMULI [J].
KIMURA, J .
BRAIN, 1973, 96 :87-96