THE DESIGN OF TRIALS FOR PREVENTION OF IDDM

被引：37

作者：

EISENBARTH, GS ^{[1
]}

VERGE, CF ^{[1
]}

ALLEN, H ^{[1
]}

REWERS, MJ ^{[1
]}

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT PREVENT MED & BIOMETR,DENVER,CO 80262

来源：

DIABETES | 1993年 / 42卷 / 07期

关键词：

D O I：

10.2337/diabetes.42.7.941

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several large clinical trials for the prevention of IDDM in islet cell antibody positive first-degree relatives are planned or underway. The design of these trials rests in part on assumptions about the natural history of autoimmunity during the prediabetic period and on the likely effectiveness of the intervention being tested. At this time, most of the factors that influence the required sample size can only be roughly estimated.

引用

页码：941 / 947

页数：7

共 39 条

[1] IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].

BAEKKESKOV, S ;

AANSTOOT, HJ ;

CHRISTGAU, S ;

REETZ, A ;

SOLIMENA, M ;

CASCALHO, M ;

FOLLI, F ;

RICHTEROLESEN, H ;

CAMILLI, PD .

NATURE, 1990, 347 (6289) :151-156

[2] STANDARDIZATION OF IVGTT TO PREDICT IDDM [J].

BINGLEY, PJ ;

COLMAN, P ;

EISENBARTH, GS ;

JACKSON, RA ;

MCCULLOCH, DK ;

RILEY, WJ ;

GALE, EAM .

DIABETES CARE, 1992, 15 (10) :1313-1316

[3] QUANTIFICATION OF ISLET-CELL ANTIBODIES AND PREDICTION OF INSULIN-DEPENDENT DIABETES [J].

BONIFACIO, E ;

BINGLEY, PJ ;

SHATTOCK, M ;

DEAN, BM ;

DUNGER, D ;

GALE, EAM ;

BOTTAZZO, GF .

LANCET, 1990, 335 (8682) :147-149

[4]

Casagrande J. T., 1978, APPLIED STATISTICS, V27, P176

[5] A TRIAL OF NICOTINAMIDE IN NEWLY DIAGNOSED PATIENTS WITH TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS [J].

CHASE, HP ;

BUTLERSIMON, N ;

GARG, S ;

MCDUFFIE, M ;

HOOPS, SL ;

OBRIEN, D .

DIABETOLOGIA, 1990, 33 (07) :444-446

[6] COMPARISON OF 2 COMMONLY USED STANDARD IVGTTS [J].

COLMAN, PG ;

STEWART, V ;

KEAN, J ;

KOSCHMANN, M ;

ALFORD, F ;

WARD, G ;

DEAM, D ;

HARRISON, LC .

DIABETES CARE, 1992, 15 (08) :1053-1055

[7] PREVENTION OR DELAY OF TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN CHILDREN USING NICOTINAMIDE [J].

ELLIOTT, RB ;

CHASE, HP .

DIABETOLOGIA, 1991, 34 (05) :362-365

[8] HLA-DQ-BETA-SEQUENCE POLYMORPHISM AND GENETIC SUSCEPTIBILITY TO IDDM [J].

ERLICH, HA ;

BUGAWAN, TL ;

SCHARF, S ;

NEPOM, GT ;

TAIT, B ;

GRIFFITH, RL .

DIABETES, 1990, 39 (01) :96-103

[9] THE SIZE OF CLINICAL-TRIALS IN CANCER-RESEARCH - WHAT ARE THE CURRENT NEEDS [J].

FREEDMAN, LS .

BRITISH JOURNAL OF CANCER, 1989, 59 (03) :396-400

[10] STATISTICAL DESIGNS FOR INVESTIGATING SEVERAL INTERVENTIONS IN THE SAME STUDY - METHODS FOR CANCER PREVENTION TRIALS [J].

FREEDMAN, LS ;

GREEN, SB .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1990, 82 (11) :910-914

← 1 2 3 4 →