INHIBITION OF HETEROLOGOUS DNA-REPLICATION BY THE MVMP NONSTRUCTURAL NS-1 PROTEIN - IDENTIFICATION OF A TARGET SEQUENCE

被引:8
作者
TENENBAUM, L
DUPONT, F
SPEGELAERE, P
ZENTILIN, L
NORIO, P
GIACCA, M
RIVA, S
FALASCHI, A
ROMMELAERE, J
机构
[1] INT CTR GENET ENGN & BIOTECHNOL,I-34012 TRIESTE,ITALY
[2] CNR,IST GENET BIOCHIM & EVOLUZ,I-27100 PAVIA,ITALY
[3] GERMAN CANC RES CTR,W-6900 HEIDELBERG 1,GERMANY
关键词
D O I
10.1006/viro.1993.1638
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The nonstructural protein NS-1 of minute virus of mice (MVMp), an autonomous parvovirus, trans-inhibits the replication of a chimeric plasmid containing the SV40 origin of replication (ori) embedded in the MVMp genome. It appears that a 157-bp 5′ proximal sequence of MVMp DNA is sufficient, in the presence of NS-1, to cause the inhibition of DNA replication driven by the SV40 ori placed on the same molecule. This effect is not dependent on the orientation of the MVMp target sequence and results from both a reduced level of utilization of SV40 ori and the blockage of progressing replication forks at the level of the target. Furthermore, replication driven by Epstein-Barr virus origin (oriP) is trans-inhibited by MVMp but this inhibition does not require the presence of parvoviral sequences in cis. On the basis of sequence homologies between EBV oriP and MVMp 5′ terminel sequence, it is proposed that the direct or indirect interaction of NS-1 with parvovirus-like sequences present in heterologous vital and possibly also cellular genomes may result in an inhibition of DNA replication. © 1993 Academic Press. All rights reserved.
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页码:630 / 641
页数:12
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