DUPLICATION OF THE CD8 BETA-CHAIN GENE AS A MARKER OF THE MAN GORILLA CHIMPANZEE CLADE

被引：5

作者：

DELARBRE, C

NAKAUCHI, H

BONTROP, R

KOURILSKY, P

GACHELIN, G

机构：

[1] INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,CELL GROWTH & DIFFERENTIAT LAB,TSUKUBA,JAPAN

[2] NETHERLANDS CENT ORG APPL SCI RES,INST APPL RADIOBIOL & IMMUNOL,RIJSWIJK,NETHERLANDS

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 15期

关键词：

PRIMATE; EVOLUTION; LYMPHOCYTE; ANTIGEN;

D O I：

10.1073/pnas.90.15.7049

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In earlier studies we have found that the gene encoding the CD8 beta chain is duplicated in man. We demonstrate here that the duplicated genes are both located on chromosome 2. We have also studied the moment of the duplication event relative to the evolution of higher primates by using genomic DNA of a panel of primates. Our data strongly suggest that duplication occurred after the orangutan lineage had split and before the chimpanzee, gorilla, and man clade diverged, some 8-9.5 million years ago. This result makes the CD8 beta-chain gene duplication a convenient marker for the study of the evolution of higher primates.

引用

页码：7049 / 7053

页数：5

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