INTRATHECAL ADMINISTRATION OF OXYTOCIN-INDUCED ANALGESIA IN LOW-BACK-PAIN INVOLVING THE ENDOGENOUS OPIATE PEPTIDE SYSTEM

被引：124

作者：

YANG, J

机构：

[1] Department of Nuclear Medicine, Nan Fang Hospital, Guangzhou

来源：

SPINE | 1994年 / 19卷 / 08期

关键词：

OXYTOCIN; LOW BACK PAIN; ENDOGENOUS OPIATE PEPTIDE SYSTEM; SPINAL CORD;

D O I：

10.1097/00007632-199404150-00001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Study Design. The effect of oxytocin on low back pain in patients and its mechanism in rats were investigated. Methods. Intrathecal injection, radioimmunoassay, and potassium iontophoresis tail-flick test were used to investigate the effect of oxytocin. Results. In humans, acute and chronic low back pain causes a marked change of oxytocin content within cerebral spinal fluid and plasma; oxytocin relieves low back pain (ED50 0.172 in chronic and 0.121 mug/kg in acute). In rats, oxytocin had a dose-related analgesic effect (ED50 0.067 mug/kg). At high levels, oxytocin induced locomotor ataxia (ED50 17.915 mu/kg) and death (LD50 27.224 mug/kg). Oxytocin antagonist [d(CH2)5, Tyr(Me)2, Orn8]-vasotocin and opiate receptor-blocker naloxone could reverse oxytocin-induced analgesia. Oxytocin also increased beta-endorphin, L-encephalin, and dynorphin A1-13 contents in the spinal cord, whereas oxytocin antagonist caused a decrease. Conclusions. These results suggest that oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system and may be effective and safe in acute and chronic low back pain.

引用

页码：867 / 871

页数：5

共 27 条

[1] Bodnar R.J., Nilaver G., Wallace M.M., Badillo Martinez D., Zimmerman E.A., Pain threshold changes in rats following central injection of beta-endorphin, met-enkephalin, vasopressin antisera, Int J Neurosci, 24, pp. 149-160, (1984)
[2] Buijs R.M., The specific localization of vasopressin and oxytocin pathways in the rat central nervous system, Hormones and Brain Development, pp. 233-270, (1978)
[3] Chard T., Forsling M.L., James M., Kitau M.J., Landon J., J Endocrinol, 46, pp. 532-538, (1970)
[4] Edwards C., Oxytocin, Hormone in Blood, pp. 401-472, (1979)
[5] Greenwood F.C., Hunter W.M., Gloverjs. Biochemj, 89, pp. 114-120, (1963)
[6] Han J.S., The Role of Endogenous Opioid Peptide (EOP) in Acupuncture-Induced Analgesia (AA), (1992)
[7] Lang R.E., Heil J., Ganten D., Hermann K., Unger T., Rascher W., Oxytocin unlike vasopressin is a stress hormone in the rat, Neuroendocrinology, 37, pp. 314-320, (1983)
[8] Liu W.Y., Song C.Y., Lin B.C., Yang J., The effect of intrathecal injection of oxytocin on the pain threshold in rats, J Jining Med Coll, 12, pp. 20-24, (1989)
[9] Liu W.Y., Song C.Y., Yang J., Lin B.C., Wang C.H., Involvement of oxytocin in spinal cord in acupuncture analgesia, Acupunct Res, 15, pp. 24-29, (1990)
[10] Martin R., Voigt K.H., Enkephalin co-exist with oxytocin and vasopressin in nerve terminals of rat neurohypophysis, Nature (Lond), 289, pp. 502-511, (1981)

← 1 2 3 →