BRAIN REGIONAL SEROTONIN SYNTHESIS FOLLOWING ADAPTATION TO REPEATED RESTRAINT

被引：79

作者：

HALEEM, DJ ^{[1
]}

PARVEEN, T ^{[1
]}

机构：

[1] UNIV KARACHI,NEUROCHEM & BIOCHEM PHARMACOL UNIT,KARACHI 75270,PAKISTAN

来源：

NEUROREPORT | 1994年 / 5卷 / 14期

关键词：

RESTRAINT; STRESS; 5-HT-TURNOVER; ADAPTATION; FOOD INTAKE; GROWTH RATE; HPLC; RECTAL TEMPERATURE;

D O I：

10.1097/00001756-199409080-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A single 2 h episode of restraint stress decreased food intake and growth rate of rats. These deficits were not observed after five restraint periods of 2 h a day, suggesting that adaptation occurred. An acute challenge with 2 h restraint increased 5-hydroxytryptamine (5-HT) synthesis rate in the cortex, hypothalamus, midbrain and hindbrain of previously unrestrained rats, but not those adapted to 5 days of 2 h daily restraint. Hippocampal and striatal 5-HT synthesis was not increased significantly by 2 h restraint in previously unrestrained rats but was increased and decreased, respectively, in rats exposed to five 2 h daily restraints, when they were restrained on the sixth day. The findings suggest an important role of 5-HT, particularly in the hippocampus, in adaptation to stress.

引用

页码：1785 / 1788

页数：4

共 21 条

[1] PHYSICAL EXERCISE - EVIDENCE FOR DIFFERENTIAL CONSEQUENCES OF TRYPTOPHAN ON 5-HT SYNTHESIS AND METABOLISM IN CENTRAL SEROTONERGIC CELL-BODIES AND TERMINALS [J].