A NOVEL CDNA ISOLATED FROM THE MOUSE EYE LENS ENCODING A PROTEIN WITH ZINC FINGERS AND A KRAB DOMAIN

被引：2

作者：

BRADY, JP ^{[1
]}

PIATIGORSKY, J ^{[1
]}

机构：

[1] NEI,MOLEC & DEV BIOL LAB,BETHESDA,MD 20892

来源：

DNA SEQUENCE | 1995年 / 5卷 / 06期

关键词：

KRAB DOMAIN; LENS; MOUSE; NUCLEOTIDE SEQUENCE; PCR; ZINC FINGERS;

D O I：

10.3109/10425179509020871

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A cDNA clone, pMLZ-8, was isolated from a newborn mouse eye lens cDNA library using a consensus zinc finger oligonucleotide hybridization probe. The cDNA contains an open reading frame that conceptually encodes a 606 amino acid protein. The protein possesses a ''KRAB'' domain at its amino-terminus and has a carboxy-terminal region with fifteen consensus C2H2 zinc fingers. PCR analysis reveals the presence of pMLZ-8 mRNA in lens, liver, kidney, spleen, and brain of newborn mice.

引用

页码：389 / 392

页数：4

共 17 条

[1] THE EVOLUTIONARILY CONSERVED KRUPPEL-ASSOCIATED BOX DOMAIN DEFINES A SUBFAMILY OF EUKARYOTIC MULTIFINGERED PROTEINS [J].