THE N-TERMINUS OF AMINE OXIDASE OF HANSENULA-POLYMORPHA CONTAINS A PEROXISOMAL TARGETING SIGNAL

被引：49

作者：

FABER, KN

KEIZERGUNNINK, I

PLUIM, D

HARDER, W

AB, G

VEENHUIS, M

机构：

[1] UNIV GRONINGEN,CTR BIOL,DEPT MICROBIOL,9751 NN HAREN,NETHERLANDS

[2] UNIV GRONINGEN,BIOCHEM LAB,9747 AG GRONINGEN,NETHERLANDS

来源：

FEBS LETTERS | 1995年 / 357卷 / 02期

关键词：

PEROXISOME; TOPOGENIC SIGNAL; AMINE OXIDASE; PTS2; BETA-LACTAMASE; WATERMELON MALATE DEHYDROGENASE;

D O I：

10.1016/0014-5793(94)01317-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we describe the identification of the targeting sequence of peroxisomal amine oxidase (AMO) of H. polymorpha. Deletion analysis revealed that essential targeting information is located within the extreme N-terminal 16 amino acids. Moreover, this sequence can direct a reporter protein to the peroxisomal matrix of H. polymorpha. The N-terminal 16 amino acids of AMO contain a sequence with strong homology to the conserved PTS2 sequence. Therefore, AMO is considered to be a PTS2 protein.

引用

页码：115 / 120

页数：6

共 28 条

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