THE USE OF FREE-RADICAL CYCLIZATION IN THE SYNTHESIS OF COMPOUNDS RELATED TO THE MANNOSTATINS

被引：13

作者：

INGALL, AH

MOORE, PR

ROBERTS, SM

机构：

[1] UNIV EXETER,DEPT CHEM,EXETER EX4 4QD,DEVON,ENGLAND

[2] FISONS PHARMACEUT,RES LABS,LOUGHBOROUGH LE11 0RH,LEICS,ENGLAND

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(00)86291-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A study of the potential use of 5-exo free radical cyclizations in the synthesis of carbocyclic compounds related to the mannostatins 1 and 2 is described. The dithioacetal 8 was prepared and the methyl oxime moiety utilised as an intramolecular radical trap. The stereochemistry of the products relating to the cyclization step, 10 and 11, were determined with reference to extensive nOe studies, Figs 1 and 2.

引用

页码：2155 / 2162

页数：8

共 25 条

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