THE MACROLIDE ANTIBACTERIAL ROXITHROMYCIN REDUCES BRONCHIAL HYPERRESPONSIVENESS AND SUPEROXIDE ANION PRODUCTION BY POLYMORPHONUCLEAR LEUKOCYTES IN PATIENTS WITH ASTHMA

被引：36

作者：

KAMOI, H

KURIHARA, N

FUJIWARA, H

HIRATA, K

TAKEDA, T

机构：

[1] First Department of Internal Medicine, Osaka City University Medical School, Osaka

来源：

JOURNAL OF ASTHMA | 1995年 / 32卷 / 03期

关键词：

D O I：

10.3109/02770909509089507

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We investigated the effects of a macrolide antibacterial, roxithromycin, on the generation of free radicals by peripheral polymorphonuclear leukocytes (PMNs) and on the severity of bronchial hyperresponsiveness. Ten asthmatic patients were treated for 3 months with roxithromycin, 150 mg orally once daily; such treatment significantly reduced the production of superoxide anion by PMNs (p = 0.0029) and reduced the bronchial hyperreactivity (p = 0.0016), as compared with results in healthy controls. Most of the patients required at least 2 months of treatment with roxithromycin for clinical improvement. We conclude that long-term, low-dose administration of roxithromycin may be useful in treatment of patients with bronchial asthma.

引用

页码：191 / 197

页数：7

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