STUDIES ON CHEMICAL BASIS OF CELLULAR RADIOSENSITIZATION BY 5-BROMOURACIL SUBSTITUTION IN DNA .1. PULSE- AND STEADY-STATE RADIOLYSIS OF 5-BROMOURACIL AND THYMINE

被引：110

作者：

ZIMBRICK, JD

WARD, JF

MYERS, LS

机构：

[1] Laboratory of Nuclear Medicine and Radiation Biology, UCLA School of Medicine, University of California, Los Angeles, CA, 90024

[2] Department of Radiology, UCLA School of Medicine, University of California, Los Angeles, CA, 90024

[3] Department of Radiation Biophysics, University of Kansas, Nuclear Reactor Center, Lawrence, Kansas, 66044

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE | 1969年 / 16卷 / 06期

关键词：

D O I：

10.1080/09553006914551571

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Pulse- and steady-state radiolysis techniques were combined in a comparative study of the radiation chemistry of aqueous oxygen-free solutions of 5-bromouracil (BU) and thymine (T). The results show several important differences in the radiolysis of these two molecules, which may form the chemical basis of BU sensitization. The hydrated electron (eaq-, ·CO2-, and certain organic radicals destroy BU by reactions which yield a uracilyl radical and Br-. In contrast, these species are not important in T destruction. The uracilyl radical is a transient species having a weak absorption maximum at 335 nm. It is very reactive, being able to abstract H· from a variety of molecules to form uracil and to propagate a chain reaction in formate BU solutions. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：505 / &

共 46 条

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