DIAZEPAM POTENTIATION OF PURINERGIC DEPRESSION OF CENTRAL NEURONS

被引：100

作者：

PHILLIS, JW

机构：

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1979年 / 57卷 / 04期

关键词：

D O I：

10.1139/y79-066

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intravenously or iontophoretically applied diazepam potentiated the depressant action of iontophoretically applied 5'-AMP on the spontaneous firing of rat cerebral cortical neurons. This potentiation of purinergic depression may be a result of the previously reported inhibition by diazepam of uptake of adenosine into brain tissues.

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页码：432 / 435

页数：4

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共 18 条

[1] PHARMACOLOGICAL CHARACTERIZATION OF BENZODIAZEPINE RECEPTORS IN BRAIN [J].

BRAESTRUP, C ;

SQUIRES, RF .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 48 (03) :263-270

[2] CENTRAL ACTIONS OF BENZODIAZEPINES [J].

CURTIS, DR ;

LODGE, D ;

JOHNSTON, GAR ;

BRAND, SJ .

BRAIN RESEARCH, 1976, 118 (02) :344-347

[3] DIAZEPAM AND CHLORDIAZEPOXIDE - POWERFUL GABA ANTAGONISTS IN EXPLANTS OF RAT CEREBELLUM [J].

GAHWILER, BH .

BRAIN RESEARCH, 1976, 107 (01) :176-179

[4] BENZODIAZEPINES AND CENTRAL INHIBITORY MECHANISMS [J].

GELLER, HM ;

TAYLOR, DA ;

HOFFER, BJ .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, 304 (02) :81-88

[5] ADENOSINE-ELICITED ACCUMULATION OF CYCLIC-AMP IN BRAIN-SLICES - POTENTIATION BY AGENTS WHICH INHIBIT UPTAKE OF ADENOSINE [J].

HUANG, M ;

DALY, JW .

LIFE SCIENCES, 1974, 14 (03) :489-503

[6] PURINERGIC DEPRESSION OF NEURONS IN DIFFERENT AREAS OF RAT-BRAIN [J].

KOSTOPOULOS, GK ;

PHILLIS, JW .

EXPERIMENTAL NEUROLOGY, 1977, 55 (03) :719-724

[7] ACTION OF VARIOUS ADENINE DERIVATIVES ON CEREBELLAR PURKINJE-CELLS [J].

KOSTOPOULOS, GK ;

LIMACHER, JJ ;

PHILLIS, JW .

BRAIN RESEARCH, 1975, 88 (01) :162-165

[8] BENZODIAZEPINES SPECIFICALLY MODULATE GABA-MEDIATED POSTSYNAPTIC INHIBITION IN CULTURED MAMMALIAN NEURONS [J].

MACDONALD, R ;

BARKER, JL .

NATURE, 1978, 271 (5645) :563-564

[9] ADENOSINE-DEPENDENT FORMATION OF CYCLIC-AMP IN BRAIN-SLICES [J].

MAH, HD ;

DALY, JW .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1976, 8 (01) :65-79

[10] ADENOSINE AS A PUTATIVE TRANSMITTER IN CEREBRAL-CORTEX - STUDIES WITH POTENTIATORS AND ANTAGONISTS [J].

PHILLIS, JW ;

KOSTOPOULOS, GK .

LIFE SCIENCES, 1975, 17 (07) :1085-1094