RECOGNITION OF HUMAN-IMMUNODEFICIENCY-VIRUS GLYCOPROTEINS BY NATURAL ANTI-CARBOHYDRATE ANTIBODIES IN HUMAN SERUM

被引：18

作者：

TOMIYAMA, T ^{[1
]}

LAKE, D ^{[1
]}

MASUHO, Y ^{[1
]}

HERSH, EM ^{[1
]}

机构：

[1] UNIV ARIZONA, ARIZONA CANC CTR, HEMATOL & ONCOL SECT, TUCSON, AZ 85724 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91979-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Anti-carbohydrate antibodies were isolated from Human immunodeficiency virus (HIV) negative human serum by affinity chromatography using yeast mannan followed by protein A. The purified mannan-binding IgG (MBIgG) bound to HIV glycoproteins gp160, gp120 and gp41 in Western blot. Immunofluorescence revealed that MBIgG bound to HIV IIIB-infected H9 cells but not to uninfected H9 cells, suggesting that carbohydrate structures recognized by MBIgG are specifically expressed on HIV-infected cells. MBIgG did not neutralize infectivity of HIV. These results show that normal human serum contains natural antibodies reactive to carbohydrate structures of HIV glycoproteins propagated in human cells. © 1991.

引用

页码：279 / 285

页数：7

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