PERMEABILITY OF THE BLOOD-BRAIN-BARRIER FOR ATENOLOL STUDIED BY POSITRON EMISSION TOMOGRAPHY

被引：45

作者：

AGON, P

GOETHALS, P

VANHAVER, D

KAUFMAN, JM

机构：

[1] STATE UNIV GHENT,HEYMANS INST PHARMACOL,DE PINTELAAN 185,B-9000 GHENT,BELGIUM

[2] STATE UNIV GHENT,INST NUCL SCI,B-9000 GHENT,BELGIUM

[3] STATE UNIV GHENT,ORGAN CHEM LAB,B-9000 GHENT,BELGIUM

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03545.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The permeability of the blood-brain barrier for atenolol, a hydrophilic beta-adrenergic blocking agent, has been assessed in dogs, by studying the distribution of [C-11]atenolol in brain tissue with positron emission tomography. The passage of atenolol into the brain was very limited, but a measurable small net influx into the brain tissues did occur. Osmotic opening of the blood-brain barrier resulted in a marked increase of the atenolol concentrations in brain tissue. The approach described, with sequential non-invasive measurements in brain tissue, is applicable to pharmacokinetic studies of atenolol in man.

引用

页码：597 / 600

页数：4

共 32 条

[1] ABRAHAMSSON T, 1989, DRUG METAB DISPOS, V17, P82
[2] STUDY WITH POSITRON EMISSION TOMOGRAPHY OF THE OSMOTIC OPENING OF THE DOG BLOOD-BRAIN-BARRIER FOR QUINIDINE AND MORPHINE
AGON, P
KAUFMAN, JM
GOETHALS, P
VANHAVER, D
BOGAERT, MG
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (08) : 539 - 543
[3] DRUG DISTRIBUTION IN DOG BRAIN STUDIED BY POSITRON EMISSION TOMOGRAPHY
AGON, P
BRAECKMAN, R
VANHAVER, D
DENUTTE, H
GOETHALS, P
DONCHE, H
VERMEULLEN, F
DEMAN, J
KAUFMAN, JM
[J]. BIOPHARMACEUTICS & DRUG DISPOSITION, 1988, 9 (06) : 567 - 577
[4] AGON P, 1989, POSITRON EMISSION TO, P108
[5] ANTONI G, 1989, APPL RADIAT ISOTOPES, V40, P561
[6] PROTEIN-BINDING OF ATENOLOL AND PROPRANOLOL TO HUMAN-SERUM ALBUMIN AND IN HUMAN-PLASMA
BARBER, HE
HAWKSWORTH, GM
KITTERINGHAM, NR
PETERSEN, J
PETRIE, JC
SWANN, JM
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 6 (05) : P446 - P447
[7] ATENOLOL IN THE CENTRAL NERVOUS-SYSTEM OF MONKEYS
BERZIN, B
ASSEMAN, PL
DESRY, D
VILAREM, D
THERY, C
[J]. DRUGS, 1983, 25 : 278 - 278
[8] SELECTION OF EXPERIMENTAL CONDITIONS FOR THE ACCURATE DETERMINATION OF BLOOD-BRAIN TRANSFER CONSTANTS FROM SINGLE-TIME EXPERIMENTS - A THEORETICAL-ANALYSIS
BLASBERG, RG
PATLAK, CS
FENSTERMACHER, JD
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1983, 3 (02) : 215 - 225
[9] THE CLINICAL IMPORTANCE OF CARDIOSELECTIVITY AND LIPOPHILICITY IN BETA-BLOCKERS
CRUICKSHANK, JM
[J]. AMERICAN HEART JOURNAL, 1980, 100 (02) : 160 - 178
[10] BETA-ADRENORECEPTOR-BLOCKING AGENTS AND THE BLOOD-BRAIN-BARRIER
CRUICKSHANK, JM
NEILDWYER, G
CAMERON, MM
MCAINSH, J
[J]. CLINICAL SCIENCE, 1980, 59 : S453 - S455

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