INTERFERON TRANSIENTLY MODULATES INTRANUCLEAR SIGNALING SYSTEM IN ERYTHROLEUKEMIA FRIEND-CELLS

被引：26

作者：

MISCIA, S

CATALDI, A

LISIO, R

TULIPANO, G

RIZZOLI, R

RANA, R

COCCO, L

机构：

[1] CNR, IST CITOMORFOL NORMALE & PATOL, CHIETI, ITALY

[2] UNIV BOLOGNA, IST ANAT UMANA NORMALE, I-40126 BOLOGNA, ITALY

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1991年 / 15卷 / 05期

关键词：

D O I：

10.1016/0309-1651(91)90130-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effect of human recombinant DNA interferon alpha type A on nuclear inositol lipids, diacylglycerol (DAG) and DNA metabolism has been investigated in Friend erythroleukemia cells. A transient enhancement of phosphatidylinositol (4,5) - bisphosphate (PIP2) phosphorylation together with an increase of diacylglycerol mass were observed in nuclei isolated from cells treated with interferon alpha for 90 min. At the same time, a marked reduction of DNA polymerase alpha activity was observed, suggesting a possible involvement of nuclear inositol fraction in the response of the cell nucleus to interferon treatment. © 1991.

引用

页码：427 / 435

页数：9

共 19 条

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