A POTENTIAL ANIMAL-MODEL FOR STUDYING CF HETEROZYGOTE ADVANTAGE - GENETIC-VARIATION IN THEOPHYLLINE-INDUCIBLE COLONIC CHLORIDE CURRENTS AMONG INBRED STRAINS OF MICE

被引：3

作者：

SWEET, A

ERICKSON, RP

HUNTINGTON, C

DAWSON, D

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PEDIAT & COMMUNICABLE DIS,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,SCH MED,DEPT PHYSIOL,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,SCH MED,DEPT HUMAN GENET,ANN ARBOR,MI 48109

来源：

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1992年 / 47卷 / 01期

关键词：

D O I：

10.1016/0885-4505(92)90011-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA 2J than in the C57BL 6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL 6J parental strain while colonic segments from five recombinant inbred B × D lines ranged between the C57BL 6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17. © 1992.

引用

页码：97 / 102

页数：6

共 26 条

[1] RECOMBINANT-INBRED STRAINS - AID TO FINDING IDENTITY, LINKAGE, AND FUNCTION OF HISTOCOMPATIBILITY AND OTHER GENES [J].