EFFECTS OF THE DIARYLPHOSPHINO GROUPS OF MODIFIED DIOPS ON THE ENANTIOSELECTIVITY AND THE CATALYTIC ACTIVITY OF THEIR RHODIUM(I) COMPLEXES IN THE CATALYTIC ASYMMETRIC HYDROGENATIONS OF ENAMIDES

被引：30

作者：

MORIMOTO, T ^{[1
]}

CHIBA, M ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, 52-1 YADA, OYA, SHIZUOKA 422, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 10期

关键词：

CHIRAL BISPHOSPHINE LIGAND; DIOP; ASYMMETRIC HYDROGENATION; RHODIUM(I) COMPLEX; ENAMIDE; ACETAMIDOCINNAMIC ACID; ENANTIOSELECTIVITY; CATALYTIC ACTIVITY;

D O I：

10.1248/cpb.40.2894

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Remarkable effects of the substituted diphenylphosphino groups of modified DIOPs on the enantioselectivity and the catalytic activity were observed in the asymmetric hydrogenation of an electron-rich olefin such as enamide using their rhodium(I) complexes as the catalyst. The cationic rhodium(I) complexes of modified DIOPs bearing electron-donating groups showed higher catalytic activities than that of original DIOP, and the cationic complexes showed better enantioselectivities than the corresponding neutral ones. The cationic rhodium(I) complex of p-methoxy-substituted DIOP was found to be the most efficient catalyst.

引用

页码：2894 / 2896

页数：3

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