RE-FUNCTIONALIZATION OF ALPHA-SUBSTITUTED ISOCOLCHICIDES VIA NUCLEOPHILIC TELE-SUBSTITUTION

被引：9

作者：

CAVAZZA, M ^{[1
]}

PIETRA, F ^{[1
]}

机构：

[1] UNIV TRENT,IST CHIM,I-38050 TRENT,ITALY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 07期

关键词：

D O I：

10.1039/c39940000897

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

9-Methoxyisocolchicide 1 in excess methanethiolate-methanol, or Me2SO, slowly undergoes ipso-substitution giving 9-methylthioisocolchicide 3, which then suffers tele-substitution giving 11-methylthioisocolchicide 2; this activation by dicoordinated sulfur is used for amino re-functionalisation of the isocolchicide system.

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页码：897 / 898

页数：2

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