O-BENZYL DERIVATIVES OF (S)-(+) AND (R)-(-)-2-AMINOBUTAN-1-OL AS NEW RESOLVING AGENTS FOR RACEMIC ACIDS - PRACTICAL RESOLUTIONS OF N-ACYL DERIVATIVES OF PHENYLGLYCINE AND 4-HYDROXYPHENYLGLYCINE

被引：4

作者：

TOUET, J

FAVERIEL, L

BROWN, E

机构：

[1] Laboratoire de Synthése Organique, au CNRS, Faculté des Sciences, 72017 Le Mans, avenue Olivier Messiaen

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(00)60491-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of the readily available (S)-(+) and (R)-(-)-2-aminobutan-1-ol 1 with sodium hydride followed by benzyl chloride, or a substituted benzyl halide, afforded the corresponding O underbar-benzyl bases 2-5 in high yields. These new bases are recommended for the large scale resolution of racemic acids. For instance, they proved efficient for the practical resolutions of N underbar-acetylphenylglycine (+/-)-7, N underbar-acetyl-(4-hydroxyphenyl) glycine (+/-)-9 and N underbar-chloroacetyl-(4-hydroxyphenyl) glycine (+/-)-10.

引用

页码：2957 / 2960

页数：4