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ENHANCED PROTEIN THERMOSTABILITY FROM DESIGNED MUTATIONS THAT INTERACT WITH ALPHA-HELIX DIPOLES

被引：291
作者：
NICHOLSON, H
BECKTEL, WJ
MATTHEWS, BW
机构：
[1] UNIV OREGON,DEPT PHYS,EUGENE,OR 97403
[2] UNIV OREGON,DEPT CHEM,EUGENE,OR 97403
来源：
NATURE | 1988年 / 336卷 / 6200期
关键词：
D O I：
10.1038/336651a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：651 / 656
页数：6
相关论文
共 47 条
  • [1] REPLACEMENTS OF PRO86 IN PHAGE-T4 LYSOZYME EXTEND AN ALPHA-HELIX BUT DO NOT ALTER PROTEIN STABILITY
    ALBER, T
    BELL, JA
    DAOPIN, S
    NICHOLSON, H
    WOZNIAK, JA
    COOK, S
    MATTHEWS, BW
    [J]. SCIENCE, 1988, 239 (4840) : 631 - 635
  • [2] ALBER T, 1987, METHOD ENZYMOL, V154, P511
  • [3] A GENETIC SCREEN FOR MUTATIONS THAT INCREASE THE THERMAL-STABILITY OF PHAGE-T4 LYSOZYME
    ALBER, T
    WOZNIAK, JA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (03) : 747 - 750
  • [4] CONTRIBUTIONS OF HYDROGEN-BONDS OF THR-157 TO THE THERMODYNAMIC STABILITY OF PHAGE-T4 LYSOZYME
    ALBER, T
    SUN, DP
    WILSON, K
    WOZNIAK, JA
    COOK, SP
    MATTHEWS, BW
    [J]. NATURE, 1987, 330 (6143) : 41 - 46
  • [5] ALBER T, 1986, PROTEIN STRUCTURE FO, P307
  • [6] BAASE WA, 1986, BIOPHYS J, V49, pA109
  • [7] HYDROGEN-BONDING IN GLOBULAR-PROTEINS
    BAKER, EN
    HUBBARD, RE
    [J]. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1984, 44 (02) : 97 - 179
  • [8] PROTEIN STABILITY CURVES
    BECKTEL, WJ
    SCHELLMAN, JA
    [J]. BIOPOLYMERS, 1987, 26 (11) : 1859 - 1877
  • [9] THERMAL-DENATURATION OF BACTERIOPHAGE-T4 LYSOZYME AT NEUTRAL PH
    BECKTEL, WJ
    BAASE, WA
    [J]. BIOPOLYMERS, 1987, 26 (05) : 619 - 623
  • [10] MECHANISMS OF PROTEIN AND POLYPEPTIDE HELIX INITIATION
    BLAGDON, DE
    GOODMAN, M
    [J]. BIOPOLYMERS, 1975, 14 (01) : 241 - 245
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