LONG-TERM HORMONAL SECRETION FROM THE AUTOTRANSPLANTED SHEEP PANCREAS

被引:3
作者
ARCUS, AC
BEAVEN, DW
HART, DS
HOLLAND, GW
机构
[1] PRINCESS MARGARET HOSP, CHRISTCHURCH CLIN SCH, DEPT MED, CHRISTCHURCH, NEW ZEALAND
[2] PRINCESS MARGARET HOSP, CHRISTCHURCH CLIN SCH, ENDOCRINE SERV, CHRISTCHURCH, NEW ZEALAND
[3] UNIV CANTERBURY LINCOLN COLL, CHRISTCHURCH, NEW ZEALAND
关键词
alpha-cell; autotransplantation; beta-cell; endocrine pancreas; glucagon; insulin; Pancreas; sheep; transplantation;
D O I
10.1007/BF01223622
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Seventy-five duct-ligated pancreatic segmentai autotransplants were made into bipedicled skin loops on the necks of merino ewes by vascular suture to the carotid artery and jugular vein; the in situ pancreatic remnants apparently continued to function normally. Thirty-seven were found to be active hormone secretors (secretion-rate responses to Na butyrate greater than 1 mU/min for insulin or 5 ng/min for glucagon) when first tested approximately 1 month after transplantation; 12 remained active at 1 year, 5 at 2 years, and 4 at 3 years. At first testing, the responses were (mean ±standard errors): insulin, 12.3±2.52 mU/min; glucagon, 52.6±13.5 ng/min. It is concluded that this autotransplant can, on occasion, be relatively long-lived and that it is a useful model with which to study not only pancreatic physiology but also non-immunological factors involved in survival of endocrine function in pancreatic transplants. © 1979 Springer-Verlag.
引用
收藏
页码:325 / 330
页数:6
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