CLINICAL-EVALUATION OF EFFECTS OF PRAZOSIN IN PATIENTS WITH BENIGN PROSTATIC OBSTRUCTION - A DOUBLE-BLIND, MULTIINSTITUTIONAL, PARAPROST-CONTROLLED STUDY

被引：14

作者：

YAMAGUCHI, O

SHIRAIWA, Y

KOBAYASHI, M

YOKOTA, T

OHINATA, M

AOKI, H

TSUZUKI, T

OHORI, M

机构：

[1] Departments of Urology, Fukushima Medical College, Fukushima

[2] Departments of Urology, Iwate Medical College, Morioka

来源：

UROLOGIA INTERNATIONALIS | 1990年 / 45卷

关键词：

Benign prostatic hypertrophy; Prazosin; Uroflowmetry;

D O I：

10.1159/000282029

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prazosin, a selective α1-adrenoceptor blocker, was compared with Paraprost in a double-blind, multi- institutional study in patients with benign prostatic hyperplasia. The trial encompassed 77 evaluable patients in the prazosin group and 79 in the Paraprost group. Both drugs significantly improved obstructive and irritative symptoms. Residual urine (volume or percentage of total urine) was reduced by both prazosin and Paraprost. Average and maximum flow rates increased significantly in the prazosin group while those were unchanged in the Paraprost group. Side effects occurred in 1 patient treated with prazosin (1.1%) and 3 patients with Paraprost (3.3%). Thus, we confirm the clinical value and minimal side effects of prazosin in the treatment of bladder outflow obstruction resulting from benign prostatic hyperplasia. © 1990 S. Karger AG, Basel.

引用

页码：40 / 46

页数：7

共 21 条

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