THE EFFECT OF METHIMAZOLE ON THE IMMUNE-SYSTEM IS UNLIKELY TO OPERATE DIRECTLY ON LYMPHOCYTES-T

被引:11
作者
BAGNASCO, M
VENUTI, D
CIPRANDI, G
PESCE, G
PAOLIERI, F
CANONICA, GW
机构
[1] UNIV GENOA,IST SCI MED INTERNA,CTR IMMUNOENDOCRINOL,I-16100 GENOA,ITALY
[2] UNIV GENOA,CTR ALLERGOL,I-16100 GENOA,ITALY
关键词
hyperthyroidism; interleukins; methimazole; T-cells; Thyroid;
D O I
10.1007/BF03348606
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It has been shown that the antithyroid drug methimazole (MMI) may affect B cells and possibly accessory cell function. In the present study we investigated in detail the effects of MMI on T cell in vitro proliferation. The following variables were evaluated: T cell proliferation following stimulation with phytohemoagglutinin (PHA), and anti-CD3 or anti-CD2 monoclonal antibodies; in-terleukin-2 (IL-2) and gamma-interferon (gamma-IFN) production by PHA-stimulated T cells in bulk culture and by T cell clones; PHA-induced IL-2 receptor expression; LPS-induced interleukin-1 production by accessory cells. The results obtained failed to demonstrate any effect of MMI on T cells in vitro proliferation, whatever the activation pathway considered. In addition, IL-2 and gamma-IFN productions were substantially unaffected by the drug, as well as IL-1 production by accessory cells. However, a slight reduction of PHA-induced IL-2 receptor expression was observed. Although the hypothesis of an effect of MMI on some specialized T cell functions cannot be ruled out, it is likely that the supposed “immunosuppressive” effect of the drug does not concern primarily the T lymphocyte. © 1990, Italian Society of Endocrinology (SIE). All rights reserved.
引用
收藏
页码:493 / 499
页数:7
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