RECEPTOR-STIMULATED ACTIN POLYMERIZATION REQUIRES CYTOPLASMIC ACIDIFICATION IN HUMAN-PMNS

被引：12

作者：

TONETTI, M ^{[1
]}

BUDNICK, M ^{[1
]}

NIEDERMAN, R ^{[1
]}

机构：

[1] HARVARD UNIV,SCH DENT MED,BOSTON,MA 02115

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1054卷 / 02期

关键词：

Cell movement; Cytoskeleton; Granulocyte; Hydrogen-ion concentration;

D O I：

10.1016/0167-4889(90)90236-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytoplasmic alkalinization has received considerable attention as a regulatory event In cell growth, transformation and signal transduction (Busa, W.B. (1986) Annu. Rev. Physiol. 48, 389-402 and Moolenar, W.H. (1986) Annu. Rev. Physiol. 48, 363-376). In contrast the current paper presents evidence for the role of an early cytoplasmic acidification, during signal transduction in the polymorphonuclear leukocyte (PMN). Following PMN stimulation with a chemotactic peptide, there is a significant decrease in cytoplasmic pH concomitant with a dramatic increase in cytoskeletal actin. The data indicate that this drop in pHi is necessary, but not sufficient, for signal transduction leading to cytoskeletal reorganization in these cells. © 1990.

引用

页码：154 / 158

页数：5

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[2]

BUSA WB, 1986, ANNU REV PHYSIOL, V48, P389

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