ANTICONVULSANT EFFECT OF INTRANIGRAL FLUOXETINE

被引：48

作者：

PASINI, A ^{[1
]}

TORTORELLA, A ^{[1
]}

GALE, K ^{[1
]}

机构：

[1] GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL,3900 RESERVOIR RD NN,WASHINGTON,DC 20007

来源：

BRAIN RESEARCH | 1992年 / 593卷 / 02期

关键词：

SEROTONIN; BASAL GANGLIA; DEEP PREPIRIFORM CORTEX; BICUCULLINE; GAMMA-AMINOBUTYRIC ACID;

D O I：

10.1016/0006-8993(92)91320-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bilateral focal injections of the serotonin uptake inhibitor, fluoxetine (1.75-7.0 nmol) into substantia nigra (SN) protected against convulsive seizures evoked by the focal injection of bicuculline methiodide into area tempestas, an epileptogenic site within the deep prepiriform cortex. Injection of fluoxetine unilaterally in SN or bilaterally into a site dorsal to SN was not anticonvulsant. Blockade of nigral gamma-aminobutyric acid (GABA) receptors with bicuculline in SN did not reverse the anticonvulsant action of intranigral fluoxetine. These data suggest that serotonergic transmission in SN exerts a seizure suppressing action which is independent of GABA transmission in SN.

引用

页码：287 / 290

页数：4

共 33 条

[1]

[Anonymous], 1979, STEREOTAXIC ATLAS RA

[2] INTRANIGRAL GABA ANTAGONISTS PRODUCE DOPAMINE-INDEPENDENT BITING IN RATS [J].

ARNT, J ;

SCHEELKRUGER, J .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 62 (01) :51-61

[3]

BROWNING RA, 1985, FED PROC, V44, P2425

[4] THE INFLUENCE OF STRIATAL STIMULATION AND PUTATIVE NEUROTRANSMITTERS ON IDENTIFIED NEURONS IN THE RAT SUBSTANTIA NIGRA [J].

COLLINGRIDGE, GL ;

DAVIES, J .

BRAIN RESEARCH, 1981, 212 (02) :345-359

[5]

DAILEY JW, 1992, J PHARMACOL EXP THER, V260, P533

[6] EVIDENCE THAT ACTIVATION OF GABA RECEPTORS IN THE SUBSTANTIA NIGRA SUPPRESSES SPONTANEOUS SPIKE-AND-WAVE DISCHARGES IN THE RAT [J].

DEPAULIS, A ;

VERGNES, M ;

MARESCAUX, C ;

LANNES, B ;

WARTER, JM .

BRAIN RESEARCH, 1988, 448 (01) :20-29

[7] SUPPRESSIVE EFFECTS OF INTRANIGRAL INJECTION OF MUSCIMOL IN 3 MODELS OF GENERALIZED NON-CONVULSIVE EPILEPSY INDUCED BY CHEMICAL-AGENTS [J].

DEPAULIS, A ;

SNEAD, OC ;

MARESCAUX, C ;

VERGNES, M .

BRAIN RESEARCH, 1989, 498 (01) :64-72

[8]

DESARRO G, 1985, EUR J PHARMACOL, V106, P175

[9] EVIDENCE FOR EXISTENCE OF A RAPHE PROJECTION TO SUBSTANTIA NIGRA IN RAT [J].

DRAY, A ;

GONYE, TJ ;

OAKLEY, NR ;

TANNER, T .

BRAIN RESEARCH, 1976, 113 (01) :45-57

[10] DORSAL AND MEDIAL RAPHE PROJECTIONS TO SUBSTANTIA NIGRA IN RAT - ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND BEHAVIORAL OBSERVATIONS [J].

DRAY, A ;

DAVIES, J ;

OAKLEY, NR ;

TONGROACH, P ;

VELLUCCI, S .

BRAIN RESEARCH, 1978, 151 (03) :431-442

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