GROWTH-INHIBITORY EFFECT OF NAPHTHOFURAN AND NAPHTHOFURANQUINONE DERIVATIVES ON TRYPANOSOMA-CRUZI EPIMASTIGOTES

被引：65

作者：

RIBEIRORODRIGUES, R

DOSSANTOS, WG

OLIVEIRA, AB

SNIECKUS, V

ZANI, CL

ROMANHA, AJ

机构：

[1] FIOCRUZ MS, CTR PESQUISAS RENE RACHOU, BR-30190002 BELO HORIZONTE, MG, BRAZIL

[2] UNIV FED MINAS GERAIS, FAC FARM, BR-30180 BELO HORIZONTE, MG, BRAZIL

[3] UNIV WATERLOO, DEPT CHEM, WATERLOO, ON N2L 3G1, CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 14期

关键词：

D O I：

10.1016/0960-894X(95)00248-R

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic and natural naphthofuranquinones were tested in vitro against three Trypanosoma cruzi strains with different drug susceptibility to nifurtimox and benznidazole in vivo. Four compounds exhibited high trypanocidal activity. No difference in drug susceptibility was found among the strains, therefore showing no correlation between the in vitro activity of those compounds and the in vivo results with the classic drugs.

引用

页码：1509 / 1512

页数：4

共 21 条

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